SMAD6 Mouse Monoclonal Antibody [Clone ID: 5H3]

Specifications

Product Data
Clone Name	5H3
Applications	ELISA, WB
Recommend Dilution	ELISA: 1/10000. Western Blot: 1/500 - 1/2000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of Human SMAD6 expressed in E. Coli.
Specificity	Recognizes SMAD6
Formulation	State: Ascites State: Ascitic fluid containing 0.03% Sodium Azide.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	53 kDa
Gene Name	SMAD family member 6
Database Link	Entrez Gene 4091 Human UniProt ID O43541
Background	Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions.Tissue specificity: Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.
Synonyms	SMAD family member 6, SMAD 6, SMAD-6, MADH6, MAD homolog 6
Reference Data

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