RTN3 Mouse Monoclonal Antibody [Clone ID: 1E11]

Specifications

Product Data
Clone Name	1E11
Applications	IF
Recommend Dilution	ELISA: 1/10000. Immunofluorescence: 1/200 - 1/1000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of RTN3 expressed in E. Coli.
Specificity	Recognizes Reticulon 3 (RTN3).
Formulation	State: Ascites State: Ascitic fluid containing 0.03% Sodium Azide.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	113 kDa
Gene Name	reticulon 3
Database Link	Entrez Gene 10313 Human UniProt ID O95197
Background	The reticulons are a group of highly conserved genes with preferential expression in neuroendocrine tissues. RTN3 may be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis. There are 5 isoforms.
Synonyms	ASYIP, NSPL2, NSPLII, NSP-like protein 2
Reference Data

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