AKT3 (119-136) Mouse Monoclonal Antibody [Clone ID: 66C1247.1]

Specifications

Product Data
Clone Name	66C1247.1
Applications	IHC, WB
Recommend Dilution	Immunohistochemistry on Paraffin Sections: 10 µg/ml. Western Blot: 1 - 2 µg/ml.
Reactivity	Human, Mouse, Rat, Bovine, Bat, Canine, Chicken, Equine, Monkey, Porcine, Rabbit
Host	Mouse
Clonality	Monoclonal
Immunogen	Synthetic peptide corresponding to amino acid residues 119-136 of Human Akt3
Specificity	This antibody detects V-Akt Murine Thymoma Viral Oncogene Homolog 3 (AKT3) at aa 119-136. Family: Protein Kinase Subfamily: RAC/AKT
Formulation	PBS, 0.05% BSA, 0.05% sodium azide. Sourced in TCS State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein G Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	AKT serine/threonine kinase 3
Database Link	Entrez Gene 10000 Human UniProt ID Q9Y243
Background	Akt, protein kinase B (PKB), is a serine/threonine kinase which is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activat phosphtidylinositol 3-kinase (PI 3-kinase). The major activity of Akt/PKB is to mediate cell survival. Akt/PKB is also believed to be a critical factor in the genesis of cancer as the tumor suppressor PTEN was found to antagonise PI-3 kinase and Akt/PKB kinase activity. There are 3 known isoforms of this enzyme in mammalian cells (1/alpha, 2/beta and 3/gamma). Akt1, 2 and 3 contain a key regulatory serine phosphorylation site in the carboxy-terminal region of the protein. Akt/PKB phosphorylation is critical for it activity.
Synonyms	RAC-PK-gamma, Protein kinase B gamma, PKBG, STK-2
Reference Data

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