Ltbr Rat Monoclonal Antibody [Clone ID: 5G11b]

Specifications

Product Data
Clone Name	5G11b
Applications	FC, FN
Recommend Dilution	Flow cytometry: 1/50 - 1/100. Functional assays.
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	Recombinant extracellular domain of LT beta R
Specificity	This antibody recognises lymphotoxin-beta receptor (LT beta R), a member of the tumour necrosis factor family. LT beta R is primarily expressed on stromal cells and fibroblasts and at lower levels on myeloid cell lines. Clone 5G11b specifically recognises surface expressed LT beta R. The clone is reported to be agonistic with respect to NF Kappa B activation, MIP-2 induction and IL-6 release (2). This product is routinely tested by flow cytometry on mouse WEH1 cells.
Formulation	Phosphate buffered saline pH 7.4, azide free State: Low Endotoxin State: Liquid Ig fraction
Concentration	lot specific
Purification	Affinity chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store the antibody (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Gene Name	lymphotoxin B receptor
Database Link	Entrez Gene 17000 Mouse UniProt ID P50284
Background	The protein encoded by this gene is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein specifically binds the lymphotoxin membrane form (a complex of lymphotoxin alpha and lymphtoxin beta). The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and tranformed cells. Activation of the encoded protein can trigger apoptosis.
Synonyms	Tumor necrosis factor receptor 3, TNF-R3, Tumor necrosis factor C receptor, TNFCR, TNFRSF3, D12S370, Lymphotoxin-beta receptor
Reference Data

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