Itgax Hamster Monoclonal Antibody [Clone ID: N418]

Specifications

Product Data
Clone Name	N418
Applications	FC, IHC, IP
Recommend Dilution	Immunohistochemistry on Frozen Sections. Immunoprecipitation. Flow Cytometry: Use 10 µl of 1/25-1/100 diluted antibody to label 1x106 cells in 100 µl.
Reactivity	Mouse
Host	Hamster
Clonality	Monoclonal
Immunogen	Mouse spleen dendritic cells.
Specificity	This antibody recognises the murine homologue of Human CD11c, which is a 150/90kD member of the beta 2 integrin family. In mice, CD11c is primarily expressed by dendritic cells. Clone N418 has been reported to enhance antigen specific responses when used to target dendritic cells in vivo. (Ref.3)
Formulation	PBS, pH 7.4 containing 0.09% Sodium Azide as preservative. State: Purified State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Affinity Chromatography on Protein G.
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	integrin alpha X
Database Link	Entrez Gene 16411 Mouse UniProt ID Q9QXH4
Background	CD11c (integrin alpha X chain protein) combines with the beta 2 chain (ITGB2) to form a leukocyte specific integrin referred to as inactivated C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. The CD11c antigen is a marker for hairy cell leukaemia.
Synonyms	ITGAX, Integrin alpha-X, Leu M5
Reference Data

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