Cytochrome P450 2A6 (CYP2A6) Mouse Monoclonal Antibody [Clone ID: F16 P2 D8]

Specifications

Product Data
Clone Name	F16 P2 D8
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA. Immunohistochemistry on paraffin sections. Western Blot: 1 - 2 µg/ml.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with Synthetic peptide conjugated to ovalbumin derived from the C-terminus of CYP2A6 and mouse myeloma Ag8563 cells. Antigen identical in CYP2A6, 2A7 and 2A13.
Specificity	This antibody reacts to Cytochrome p450 2A6.
Formulation	Phosphate buffered saline with 0.08% sodium azide State: Purified State: Liquid purified Ig
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	The antibody can be shipped at ambient temperature. Store (in aliquots) at -20°C only. Avoid repeated freezing and thawing.
Gene Name	cytochrome P450 family 2 subfamily A member 6
Database Link	Entrez Gene 1548 Human UniProt ID P11509
Background	The cytochrome P450 proteins (CYPs) are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. P450 enzymes are classified into subfamilies based on their sequence similarities. CYP2A6 is a liver enzyme that metabolizes a number of drugs and a variety of procarcinogens, though it is primarily responsible for the metabolism of nicotine, the major addictive agent in tobacco. CYP2A6 inactivates nicotine to cotinine, and then cotinine to 3-hydroxycotinine. Differences in CYP2A6 genotypes are related to nicotine dependence, and may influence smoking habits and withdrawal symptoms in individuals that are quitting smoking. This suggests that an individualized smoking cessation program may be designed based on CYP2A6 genotypes.
Synonyms	CYP2A3,Cytochrome P450 2A6, CYPIIA6, CYPIIA3
Reference Data

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