NPDC1 Mouse Monoclonal Antibody [Clone ID: 16E4]

Specifications

Product Data
Clone Name	16E4
Applications	WB
Recommend Dilution	Western Blot: 1:1000. Positive Control: Brain tissue lysate (mouse and rat tested, human not yet tested).
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Hybridoma produced by the fusion of splenocytes from mice immunized with a synthetic peptide derived from human NPDC-1 protein and mouse myeloma cells.
Specificity	This antibody react to NPDC-1.
Formulation	20 mM sodium phosphate, 150 mM sodium chloride, 50% glycerol, pH 7.5, 3mM sodium azide State: Purified State: Liquid purified Ig
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	The antibody can be shipped at 2-8°C. Store (in aliquots) at -20°C only. Avoid repeated freezing and thawing.
Gene Name	neural proliferation, differentiation and control, 1
Database Link	Entrez Gene 56654 Human UniProt ID Q9NQX5
Background	The discovery of NPDC-1 (neuronal proliferation, differentiation and control protein 1) was the result of a study of genes that were preferentially expressed in immortalized neural precursor cell lines at the onset of contact inhibition of proliferation and subsequent differentiation. It was further found that transfection of transformed cells with NPDC-1 led to increased doubling times and suppression of many characteristics of transformation. NPDC-1 is differentially expressed in brain and lung and has been shown to interact directly with the transcription factor E2F-1 as well as D-type cyclins and cdk2. NPDC-1 has been identified as a modulator of transcriptiona levents mediated by retinoic acid and the protein level and activity of NPDC-1 have been shown to be regulated by phosphorylation mediated proteasomal degradation.
Synonyms	NPDC-1
Reference Data

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