Rb (RB1) Mouse Monoclonal Antibody [Clone ID: C36]

Specifications

Product Data
Clone Name	C36
Applications	IP
Recommend Dilution	Immunoprecipitation.
Reactivity	Chicken, Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant protein corresponding to amino acids 300 to 380 of the human retinoblastoma sequence.
Specificity	Retinoblastoma binds and regulates E2F transcription factors.
Formulation	PBS containing 0.08% Sodium Azide as preservative. State: Purified State: Liquid (sterile filtered) purified IgG fraction.
Concentration	lot specific
Purification	From ascites.
Conjugation	Unconjugated
Storage Condition	Store the antibody at -20°C. Avoid repeated freezing and thawing.
Gene Name	RB transcriptional corepressor 1
Database Link	Entrez Gene 5925 Human UniProt ID P06400
Background	Retinoblastoma encodes a phosphorylated protein p110 and binds and regulates E2F transcription factors. Rb functions as a major cell cycle regulator by its ability to repress gene transcription by all three RNA polymerases. In its hypophosphorylated form, Rb binds to a subset of E2F containing complexes converting them to repressors preventing expression of E2F target genes. These complexes repress transcription via E2F binding elements in the promotersof cell cycle control genes, such as E2F-1, c-myc, and cdc2 genes.
Synonyms	Retinoblastoma 1, Rb, p105-Rb, pRb, pp110, OSRC
Reference Data

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