RBL1 Mouse Monoclonal Antibody [Clone ID: KAB6]

Specifications

Product Data
Clone Name	KAB6
Applications	WB
Recommend Dilution	Suitable for Western Blots at 1/1000.
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	GST fusion protein to the N terminus of p107.
Specificity	KAB6 recognizes both the phosphorylated and unphosphorylated forms of p107 at a MW of 107 kDa.
Formulation	PBS containing 0.08% Sodium Azide as preservative. State: Purified State: Liquid (sterile filtered) purified IgG fraction.
Concentration	lot specific
Purification	Protein A/G chromatography (> 95 % by SDS-PAGE).
Conjugation	Unconjugated
Storage Condition	Store the antibody at -20°C. Avoid repeated freezing and thawing.
Gene Name	RB transcriptional corepressor like 1
Database Link	Entrez Gene 5933 Human UniProt ID P28749
Background	P107 is related both in structure and function to the retinoblastoma tumor suppressor protein and p130 (collectively known as pocket proteins) and are known to regulate the activity of E2F transcription factors. E2F transcription factors regulate the expression of a number of genes important in cell proliferation, particularly those involved in the progression through G1 and into the S-phase of the cell cycle. Binding of p107 converts E2F transcription factors from transcriptional activators to transcriptional repressors.
Synonyms	Retinoblastoma-like protein 1, 107 kDa retinoblastoma-associated protein, p107, pRb1
Reference Data

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