CD11b (ITGAM) Mouse Monoclonal Antibody [Clone ID: MEM-170]
CAT#: AM03120AF-N
CD11b (ITGAM) mouse monoclonal antibody, clone MEM-170, Azide Free
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CNY 3,140.00
货期*
5周
规格
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Specifications
Product Data | |
Clone Name | MEM-170 |
Applications | FC, FN |
Recommend Dilution | Flow Cytometry: 1 µg/ml. Functional Application: The antibody MEM-170 blocks (not completely) Mac-1-mediated neutrophil binding to fibrinogen. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Human granulocytes |
Specificity | The antibody recognizes CD11b antigen (Mac-1), a 165 kDa transmembrane protein type 1 mainly expressed on monocytes, granulocytes and NK-cells. The antibody blocks (not completely) Mac-1-mediated neutrophil binding to fibrinogen. |
Formulation | Azide free phosphate buffered saline (PBS), preserved by filter sterilization, approx. pH 7.4 State: Azide Free State: Liquid Ig fraction |
Concentration | lot specific |
Purification | Protein G affinity chromatography; purity: > 95% (by SDS-PAGE) |
Conjugation | Unconjugated |
Storage Condition | Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. |
Gene Name | integrin subunit alpha M |
Database Link | |
Background | CD11b (integrin aM subunit) is a 165 kDa type I transmembrane glycoprotein that non-covalently associates with integrin b2 subunit (CD18); expression of the CD11b chain on the cell surface requires the presence of the CD18 antigen. CD11b/CD18 integrin (Mac-1, CR3) is highly expressed on NK cells, neutrophils, monocytes and less on macrophages. CD11b/CD18 integrin is implicated in various adhesive interactions of monocytes, macrophages and granulocytes, facilitating their diapedesis, as well as it mediates the uptake of complement coated particles, serving as a receptor for the iC3b fragment of the third complement component. |
Synonyms | ITGAM, CR3A, CR-3 alpha chain, Integrin alpha-M, MAC1 |
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