PSMA (FOLH1) (44-750) Mouse Monoclonal Antibody [Clone ID: GCP-05]

CAT#: AM03114RP-N

PSMA (FOLH1) (44-750) mouse monoclonal antibody, clone GCP-05, PE

Conjugation: Unconjugated PE



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CNY 5,790.00


货期*
5周

规格
    • 100 ug

Cited in 3 publications.

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Specifications

Product Data
Clone Name GCP-05
Applications FC
Recommend Dilution Flow Cytometry: 1/200.
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Amino acids 44-750 of Human PSMA / FOLH1
Specificity This antibody recognizes extracellular domain of Glutamate Carboxypeptidase II (NAALADase, FOLH1, PSMA), an approximately 95-110 kDa transmembrane glycoprotein expressed mainly in tumour neovasculatures, nervous system and jejunum, which is an important prostate tumour marker.
Formulation Phosphate buffered saline (PBS)
Label: PE
State: Liquid purified Ig fraction
Preservative: 15 mM Sodium Azide
Label: Conjugated with R-Phycoerythrin under optimum conditions.
Concentration lot specific
Purification Size-Exclusion Chromatography
Conjugation PE
Storage Condition Store undiluted at 2-8°C.
DO NOT FREEZE!
This product is photosensitive and should be protected from light.
Gene Name folate hydrolase (prostate-specific membrane antigen) 1
Background Glutamate carboxypeptidase II (GCPII), also known as N-acetyl-alpha-linked acidic dipeptidase I (NAALADase I), folate hydrolase (FOLH1), and prostate-specific membrane antigen (PSMA), is an approximately 95-110 kDa type II transmembrane glycoprotein expressed in various tissues. In nervous system GCPII cleaves abundant N-acetylaspartylglutamate, which is released from neurons in a calcium-dependent manner, to N-acetylaspartate and glutamate. As immoderate glutamate concentration is neurotoxic, GCPII contributes to pathological conditions regarding e.g. Alzheimer´s disease, Huntington´s disease, epilepsy, schizophrenia, stroke or neuropathic pain and appears to be an interesting therapeutic target. In jejunum GCPII hydrolyzes pteroylpoly-gamma-glutamate to folate and glutamate, enabling folate to be absorbed by gastrointestinal tract. GCPII, which is present in a number of tissues at low levels, is overexpressed in neovasculature of most solid tumours and is a target enzyme for diagnosis and treatment of prostate cancer. Normal human prostate express more mRNA coding for a cytosolic GCPII form truncated at the N-terminus (PSM´) than mRNA for membrane-bound GCPII, and this ratio is reversed upon malignant transformation.
Synonyms Glutamate carboxypeptidase 2, Folate hydrolase 1, Prostate-specific membrane antigen, FOLH, NAALAD1, PSM, GCP2, NAALAdase
Reference Data
Protein Families Druggable Genome, Protease, Transmembrane
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations (3)

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