DR5 (TNFRSF10B) Mouse Monoclonal Antibody [Clone ID: DR5-01-1]

CAT#: AM03099PU-N

DR5 (TNFRSF10B) mouse monoclonal antibody, clone DR5-01-1, Aff - Purified

Conjugation: Unconjugated FITC PE



Need it in bulk or conjugated?
Get a free quote

CNY 3,810.00


货期*
5周

规格
    • 100 ug

Product images

Specifications

Product Data
Clone Name DR5-01-1
Applications FC
Recommend Dilution Flow Cytometry: 1-10 μg/ml
Positive Control: Jurkat Human peripheral blood leukemia T cell line.
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Recombinant fusion protein of Human IgG heavy chain and extracellular domain of DR5.
Specificity The antibody DR5-01-1 recognizes an extracellular domain of TRAIL-R2 (DR5). TRAIL-R2 is one of two TNF superfamily member intracellular death domain containing receptors for TRAIL (APO2L).
Formulation PBS, pH 7.4 with 15 mM Sodium Azide as preservative.
State: Aff - Purified
State: Liquid purified IgG fraction (> 95% pure by SDS-PAGE).
Concentration lot specific
Purification Protein-A Affinity Chromatography.
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Gene Name tumor necrosis factor receptor superfamily member 10b
Background TRAIL-R2 (CD262, DR5) is one of two TNF superfamily member intracellular death domain containing receptors for TRAIL (APO2L).
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including tumor necrosis factor (TNF) and Fas ligand in the TNF family through their death domain containing receptors, TNF receptor 1 (TNFR1) and Fas, respectively. Another member in the TNF family has been identified and designated TRAIL (for TNF related apoptosis inducing ligand) and Apo2L (for Apo2 ligand). Receptors for TRAIL include two death domain containing receptors, DR4 and DR5, as well as two decoy receptors, DcR1 and DcR2, lacking the intracellular signaling death domain. DcR1 (also called TRID), like the related death receptors DR4 and DR5, contains two extracellular cysteine rich domains. However, DcR1 contains no intracellular death domain and is thus incapable of signaling apoptosis. It has been suggested DcR1 is responsible for TRAIL resistance in normal human tissues including heart, placenta, lung, liver, kidney, spleen, and bone marrow. DR5 is a member of the TNF receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor related apoptosis inducing ligand (TNFSF10/TRAIL/APO2L), and transduces apoptosis signal. Studies with FADD deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.
Synonyms TNFRSF10B, DR5, KILLER, TRICK2, ZTNFR9, Death receptor 5, TRAIL receptor 2, TRAIL-R2
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
Customer Reviews 
Loading...