CD21 (CR2) Mouse Monoclonal Antibody [Clone ID: LT21]

Specifications

Product Data
Clone Name	LT21
Applications	FC
Recommend Dilution	Flow Cytometry analysis of Human blood cells using 20 μl reagent / 100 μl of whole blood or 106 cells in a suspension.
Reactivity	Bovine, Canine, Human, Porcine
Host	Mouse
Clonality	Monoclonal
Immunogen	IM9 human B-lymphoblastoid cell line
Specificity	The antibody LT21 reacts with CD21 (CR2), a 145 kDa transmembrane glycoprotein (complement C3d receptor - C3dR) expressed on B lymphocytes, follicular dendritic cells, some epithelial cells and a subsets of T lymphocytes. It is not expressed on immature B cells.
Formulation	PBS Label: FITC State: Liquid purified IgG fraction Preservative: 15 mM Sodium Azide Label: Conjugated with Fluorescein isothiocyanate under optimum conditions.
Conjugation	FITC
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Gene Name	complement component 3d receptor 2
Database Link	Entrez Gene 1380 Human UniProt ID P20023
Background	CD21 (complement receptor 2, CR2) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to folicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands.
Synonyms	Complement receptor type 2, CR2, C3DR, C3d receptor, EBV Receptor, Dendritic Cell Marker
Reference Data

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