CD95 (FAS) Mouse Monoclonal Antibody [Clone ID: LT95]
CAT#: AM03061FC-N
CD95 (FAS) mouse monoclonal antibody, clone LT95, FITC
Conjugation: Unconjugated APC PE
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CNY 3,810.00
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Specifications
Product Data | |
Clone Name | LT95 |
Applications | FC |
Recommend Dilution | This antibody is suitable for Flow Cytometry analysis of human blood cells using 20 μl reagent/100 μl of whole blood or 10e6 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | HUT-78 human T cell lymphoma cell line |
Specificity | The antibody LT95 reacts with CD95 (Fas/APO-1), a 46 kDa single chain type I glycoprotein of the tumour necrosis factor/nerve growth factor (TNF/NGF) receptor superfamily, expressed on a variety of normal and neoplastic cells. It seems that the antibody LT95 does not induce Fas mediated apoptosis, although it cross-blocks anti-Fas DX2 antibody that recognizes a functional epitope of Fas molecule. |
Formulation | PBS containing 15 mM sodium azide as preservative and 0.2% (w/v) high-grade BSA (Protease free) as stabilizer. Label: FITC State: Liquid purified IgG fraction. Label: Conjugated with Fluorescein isothiocyanate under optimum conditions |
Conjugation | FITC |
Storage Condition | Store the antibody in the dark at 2-8°C. Do Not Freeze! Avoid prolonged exposure to light. |
Gene Name | Fas cell surface death receptor |
Database Link | |
Background | CD95 (Fas, APO-1), a 46 kDa transmembrane glycoprotein, is a cell death receptor of the TNFR superfamily. Stimulation of CD95 results in aggregation of its intracellular death domains, formation of the death-inducing signaling complex (DISC) and activation of caspases. In type I cells caspase 3 is activated by high amounts of caspase 8 generated at the DISC, in type II cells low concentration of caspase 8 activates pathway leading to the release of cytochrome c from mitochondria and activation of caspase 3 by cytochom c. Besides its roles in induction of apoptosis, Fas also triggers pro-inflammatory cytokine responses. |
Synonyms | FASLG receptor, Apo-1 antigen, APT1, FAS1, TNFRSF6 |
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