DcR1 (TNFRSF10C) Mouse Monoclonal Antibody [Clone ID: TRAIL-R3-02]

Specifications

Product Data
Clone Name	TRAIL-R3-02
Applications	FC
Recommend Dilution	Flow Cytometry: 3 µg/ml.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	TRAIL-R3 (aa 1-280) - hIgGhc fusion protein.
Specificity	The antibody TRAIL-R3-02 reacts with TRAIL-R3, a 35 kDa GPI-anchored extracellular membrane protein expressed mainly on neutrophils.
Formulation	PBS containing 15 mM Sdium Azide as preservative and 0.2% (w/v) high-grade (Protease free) BSA as a stabilizing agent. Label: FITC State: Liquid purified IgG fraction. Label: Fluorescein Isothiocyanate Isomer 1
Concentration	lot specific
Conjugation	FITC
Storage Condition	Store the antibody undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Avoid prolonged exposure to light.
Gene Name	tumor necrosis factor receptor superfamily member 10c
Database Link	Entrez Gene 8794 Human UniProt ID O14798
Background	TRAIL-R3 (CD263, TR3, DcR1, LIT, TRID), expressed mainly on neutrophils, belongs to receptors of TRAIL, a TNF-like membrane cytotoxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R3, however, is a GPI-anchored protein that lacks cytoplasmic death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by competing for binding of TRAIL with death receptor 5 (DR5).
Synonyms	Decoy receptor 1, TNFRSF10C, DCR1, LIT, TRID, TRAIL receptor 3, TRAIL-R3
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity

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