HLA Class I ABC Mouse Monoclonal Antibody [Clone ID: W6/32]

Specifications

Product Data
Clone Name	W6/32
Applications	FC
Recommend Dilution	Flow Cytometry (1/300 as starting dilution).
Reactivity	Bovine, Feline, Human, Primate
Host	Mouse
Clonality	Monoclonal
Immunogen	Membrane of Human tonsil cells
Specificity	The antibody W6/32 recognizes virtually all nucleated human cells. It is a valuable reagent for analysing variations in HLA class I expression in different disease states e.g. liver disease, muscular dystrophy, inflammatory myopathy and other neuromuscular disorders. This antibody W6/32 is also suitable as a Positive Control for HLA tissue typing and crossmatching.
Formulation	Phosphate buffered saline (PBS), pH~7.4 Label: FITC State: Liquid purified IgG fraction Preservative: 15 mM Sodium Azide Label: Conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC.
Concentration	lot specific
Conjugation	FITC
Storage Condition	Store the antibody undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Background	HLA-class I major histocompatibility (MHC) antigens are intrinsic membrane glycoproteins expressed on nucleated cells and noncovalently associated with an invariant beta-2 microglobulin. They carry foreign determinants important for immune recognition by cytotoxic T cells, thus important for anti-viral and anti-tumour defence. Human HLA-class I antigens are represented by HLA-A, HLA-B and HLA-C molecules. MHC Class I molecules (MHC Class Ia) are expressed on the surface of all human cell types.
Synonyms	MHC class I ABC, HLA Class 2 ABC
Reference Data

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