Myostatin Propeptide (MSTN) Mouse Monoclonal Antibody [Clone ID: 4D]

Specifications

Product Data
Clone Name	4D
Applications	ELISA
Recommend Dilution	ELISA.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant Myostatin full-length precursor (aa 1-352)
Specificity	This antibody detects Myostatin prodomain.
Formulation	50 mM TRIS, pH 7.4 State: Purified State: Lyophilized purified IgG fraction
Reconstitution Method	Restore in aqua bidest to 1 mg/ml.
Purification	Protein G Chromatography
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C and reconstituted at -20°C. Avoid repeated freezing and thawing.
Gene Name	myostatin
Database Link	Entrez Gene 2660 Human UniProt ID O14793
Background	Myostatin (GDF8) is expressed uniquely in human skeletal muscle as a 12 kDa mature glycoprotein consisting of 113 amino acid residues and secreted into plasma. Myostatin is a member of the transforming growth factor ß superfamily of secreted growth and differentiation factors that is essential for proper regulation of skeletal muscle mass. Studies have shown that myostatin could play an important role in cardiac development and physiology. In serum, myostatin circulates as part of a latent complex containing myostatin propeptide and/or follistatin-related gene. The myostatin propeptide is known to bind and inhibit myostatin in vitro. This interaction is relevant in vivo, with a majority (>70%) of myostatin in serum bound to its propeptide. The myostatin propeptide is negative regulator of myostatin in vivo.
Synonyms	MSTN, GDF8, GDF-8, Growth differentiation factor 8
Reference Data

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