Factor H (CFH) Mouse Monoclonal Antibody [Clone ID: 10-10]

Specifications

Product Data
Clone Name	10-10
Applications	ELISA, FC, IHC, WB
Recommend Dilution	ELISA. Western Blot. Flow Cytometry. Immunohistochemistry on Frozen Sections. Recommended Positive Control: Kidney from post streptoccal glomerulonephritis patients.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified human factor H from serum.
Specificity	This antibody recognises Complement Factor H which exists in 2 forms.
Formulation	Borate buffered saline pH 8.4 containing 0.02% Sodium Azide as preservative. State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Purification	Affinity Chromatography on Protein A.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	complement factor H
Database Link	Entrez Gene 3075 Human UniProt ID P08603
Background	Complement factor H exists in 2 forms, the most common form, of 150kDa, and the less common form of 43 kDa. Factor H is secreted by the liver into the blood serum. It is important in regulating the complement pathway, preventing unnecessary inflammation which can damage the host tissue. Factor H functions as a cofactor in the inactivation of C3b by factor I. It makes C3b susceptible to cleavage by factor I, resulting in iC3b. Factor H also inhibits the formation of the C3bBb complex (C3 convertase) and increases the rate of dissociation of both C3 convertase and the (C3b)NBB complex (C5 convertase). This prevents these components of the classical and of alternative complement pathways from forming a positive feedback loop. Mutations in factor H are associated with hemolytic-uremic syndrome, age-related macular degeneration, membranoproliferative glomerulonephritis (MPGN) type II and chronic hypocomplementemic nephropathy.
Synonyms	CFH, HF, HF1, HF2, H factor 1
Reference Data

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