Influenza A (Nucleoprotein N1) Mouse Monoclonal Antibody [Clone ID: A1]

Specifications

Product Data
Clone Name	A1
Applications	IF, IHC
Recommend Dilution	Immunofluorescence. Immunohistochemistry on Frozen Sections.
Reactivity	Influenza A Virus
Host	Mouse
Clonality	Monoclonal
Specificity	This antibody recognises the Influenza type A nucleoprotein. It demeostrates stronger binding with N1 type influenza A. No cross reactivity is seen with influenza B or other respiratory viruses. Reactivity with virus isolated from other species has not been confirmed with the exception of Avian H5N1 strain.
Formulation	PBS containing 0.09% Sodium Azide State: Purified State: Liquid purified IgG fraction
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Background	The nucleoprotein (NP) of Influenza virus encapsulates the negative strand of the viral RNA and is essential for replicative transcription. It may also be involved in other essential functions throughout the virus life cycle. As well as binding ssRNA, NP is able to self associate to form large oligomeric complexes. NP is able to interact with a variety of other macromolecules of both viral and cellular origins. It binds the PB1 and PB2 subunits of the polymerase and the matrix protein M1. NP has also been shown to interact with at least four cellular polypeptide families: nuclear import receptors of the importin class, filamentous (F) actin, the nuclear export receptor CRM1 and a DEAD box helicase BAT1/UAP56" (Portela et al 2002).
Synonyms	Influenza A Virus, Seasonal Flu
Reference Data

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