CD13 (ANPEP) Mouse Monoclonal Antibody [Clone ID: 22A5]

Specifications

Product Data
Clone Name	22A5
Applications	FC, IHC
Recommend Dilution	Suitable for use in Flow Cytometry and Immunohistochemistry (acetone-fixed frozen sections). We recommend using 1 µg to stain 1.0 x 10e6 cells in Flow Cytometric applications.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	A cell suspension containing osteoclasts from osteoclastomas
Specificity	This antibody recognizes the (Mr 150-170kDa) cell surface glycoprotein expressed in a pan-myeloid fashion. This antibody also reacts with osteoclasts in giant cell tumors of bone (osteoclastoma), clear cell chondrosarcoma and aneurysmal bone cysts.
Formulation	0.01M PBS, pH 7.2 containing 2mM EDTA, 1% BSA as stabilizer and 0.09% Sodium Azide as preservative. Label: Biotin State: Liquid purified Ig fraction.
Concentration	lot specific
Purification	Protein G Chromatography.
Conjugation	Biotin
Storage Condition	Store the antibody undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	alanyl aminopeptidase, membrane
Database Link	Entrez Gene 290 Human UniProt ID P15144
Background	CD13 also known as Aminopeptidase N is a zinc dependent exopeptidase which cleaves amino acids from the N-termini of target proteins including neuropeptides and cytokines. CD13 is expressed on all cells of the myeloid lineage as well as epithelial cells of the intestine, placenta, liver and kidney. CD13 is upregulated in a number of tumour types including lung, melanoma, thyroid and hepatocarcinoma and has been shown to correlate with poor prognosis. CD13 is a crucial molecule in tumour angiogenesis. CD13 is also the receptor for viruses from the coronavirus family.
Synonyms	Aminopeptidase N, ANPEP, APN, PEPN
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.