Amyloid beta (1-42 specific) Mouse Monoclonal Antibody [Clone ID: 8G7]

CAT#: AM00003PU-N

Amyloid beta (1-42 specific) mouse monoclonal antibody, clone 8G7, Purified

Conjugation: Unconjugated Biotin FITC



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CNY 5,148.00


货期*
5周

规格
    • 100 ug

Cited in 1 publication.

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Specifications

Product Data
Clone Name 8G7
Applications ELISA, IF, WB
Recommend Dilution ELISA: 0.05 µg/ml.
Immunoblotting: 1.0 µg/ml for HRPO/ECL detection.
Recommended buffer: Casein/Tween20 based blocking and blot incubation buffer.
Immunocytochemistry: 0.1-1 µg/ml.
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen C-terminal peptide (aa 1-42) of Amyloid beta A4 - conjugated to KLH
Specificity This antibody specifically interacts with the C-Terminus of beta-Amyloid (1-42) and does not crossreact with beta-Amyloid (1-40).
Formulation 1ml 2 x PBS/0.09% Sodium Azide/PEG and Sucrose
State: Purified
State: Lyophilized purified IgG fraction
Reconstitution Method Restore with 1.0 ml H2O (15 min, RT).
Purification Subsequent Thiophilic Adsorption and Size Exclusion Chromatography
Conjugation Unconjugated
Storage Condition For long-term storage, freeze lyophilizate upon arrival (-20°C).
Upon reconstitution, aliquote and freeze in liquid nitrogen; reconstituted antibody can be stored frozen at -20°C to -80°C up to 1 year. Thaw aliquots at 37°C.
Thawed aliquots may be stored at 2-8°C up to 3 months.
Avoid repeated freeze-thaw cycles.
Background The beta-amyloid peptide (beta A4), proteolytically released from the amyloid precursor protein (APP), is the principal component of senile plaques in Alzheimer's disease. Cleavage of APP by alpha-secretase or alternatively by beta-secretase leads to generation and extracellular release of soluble APP peptides, S-APP-alpha and S-APP-beta, respectively, and the retention of corresponding membrane-anchored C-terminal fragments, C83 and C99. Subsequent processing of C83 by gamma-secretase yields P3 peptides. This is the major secretory pathway and is nonamyloidogenic. Alternatively, presenilin/nicastrin-mediated gamma-secretase processing of C99 releases the amyloid beta proteins, amyloid-beta 40 (Abeta40) and amyloid-beta 42 (Abeta42), major components of amyloid plaques, and the cytotoxic C-terminal fragments, gamma-CTF(50), gamma-CTF(57) and gamma-CTF(59).
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations (1)

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