Artemis (DCLRE1C) (NM_022487) Human Recombinant Protein

Specifications

Product Data
Species	Human
Expression Host	E. coli
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) A DNA sequence encoding the region full length of DCLRE1C
Tag	N-GST and C-HIS
Predicted MW	65.3 kDa
Concentration	>0.05 µg/µL as determined by microplate BCA method
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer	50mM Tris, pH8.0, 8M Urea
Storage	Store at -80°C after receiving vials.
Stability	Stable for at least 1 year from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq	NP_071932
Locus ID	64421
UniProt ID	Q96SD1
Refseq Size	6242
Cytogenetics	10p13
Refseq ORF	1731
Synonyms	A-SCID; DCLREC1C; RS-SCID; SCIDA; SNM1C
Summary	This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The encoded protein has single-strand-specific 5'-3' exonuclease activity; it also exhibits endonuclease activity on 5' and 3' overhangs and hairpins. The protein also functions in the regulation of the cell cycle in response to DNA damage. Mutations in this gene can cause Athabascan-type severe combined immunodeficiency (SCIDA) and Omenn syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Protein Families	Druggable Genome
Protein Pathways	Cell cycle, Non-homologous end-joining, Primary immunodeficiency

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