Tnfrsf4 (20-211, hIgG-His-Tag) Mouse Recombinant Protein

Specifications

Product Data
Species	Mouse
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) VTARRL NCVKHTYPSG HKCCRECQPG HGMVSRCDHT RDTLCHPCET GFYNEAVNYD TCKQCTQCNH RSGSELKQNC TPTQDTVCRC RPGTQPRQDS GYKLGVDCVP CPPGHFSPGN NQACKPWTNC TLSGKQTRHP ASDSLDAVCE DRSLLATLLW ETQRPTFRPT TVQSTTVWPR TSELPSPPTL VTPEGP
Tag	hIgG-His-Tag
Predicted MW	48.6kDa (435aa)
Concentration	0.25mg/ml (determined by Absorbance at 280nm)
Purity	> 95% by SDS-PAGE
Buffer	Liquid. In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Applications	SDS-PAGE, Bioactivity
Storage	Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Bioactivity	Measured by its binding ability in a functional ELISA with Mouse OX40 Ligand/TNFSF4 (CAT# ATGP4022). The ED50 range ≤ 0.4 ug/ml.
Endotoxin	< 1 EU per 1ug of protein (determined by LAL method)
Reference Data
RefSeq	NP_035789.1
UniProt ID	P47741
Synonyms	Tumor necrosis factor receptor superfamily member 4, TNFRSF4, ACT35, CD134, IMD16, OX40, TXGP1L, ACT35 antigen, OX40L receptor, TAX transcriptionally-activated glycoprotein 1 receptor
Summary	TNFRSF4, also known as CD134, is a member of the TNFR-superfamily of receptors. This protein is a receptor for TNFSF4/OX40L/GP34 and a costimulatory molecule implicated in long-term T-cell immunity. OX40-OX40L interactions regulate antigen-specific T-cell expansion and survival, cytokine production. It also modulates cytokine receptor signalling. Therefore the interaction between TNFRSF4 and CD40L plays a key role in the development of multiple imflammatry and autoimmune disease. It has been implicated in the pathologic cytokine storm associated with certain viral infections, including the H5N1 bird flu. Recombinant mouse OX40/TNFRSF4 , fused to hIgG-His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.
Protein Families	SDS-PAGE, Bioactivity

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