SARS-CoV-2 Recombinant Protein

Specifications

Product Data
Species	SARS-CoV-2
Protein Source	Human
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Arg319-Phe541(V483A)
Tag	C-6His
Buffer	Supplied as a 0.2 μm filtered solution of PBS, pH 7.4
Note	Recombinant 2019-nCoV S protein RBD Protein is produced by our Mammalian expression system and the target gene encoding Arg319-Phe541(V483A) is expressed with a 6His tag at the C-terminus.
Storage	Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening.Please minimize freeze-thaw cycles.
Stability	12 months from date of despatch
Reference Data
Synonyms	2019-nCov RBD Protein; 2019-nCoV Spike RBD Protein
Summary	The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.Some findings indicated that the mutated viruses may be evolved to acquire remarkably increased infectivity.

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