Factor X (F10) Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	Human
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Asn32-Lys488
Tag	C-Fc
Buffer	Lyophilized from a 0.2 um filtered solution of 20mM MES, 150mM NaCl, 0.2mM CaCl2, pH5.5.
Note	Recombinant Human Coagulation Factor X is produced by our Mammalian expression system and the target gene encoding Asn32-Lys488 is expressed with a Fc tag at the C-terminus.
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability	12 months from date of despatch
Reference Data
Locus ID	2159
UniProt ID	P00742
Synonyms	Coagulation factor X; Stuart factor; Stuart-Prower factor
Summary	F10, also known as Coagulation factor X, belongs to the peptidase S1 family that is synthesized as a 488 amino acid (aa) with a signal peptide and a pro region (residues 1‑40). Both the intrinsic and extrinsic pathways activate Factor X to Xa, which consists of light (residues 41‑179) and heavy (residues 235‑488) chains linked by a disulfide bond. Coagulation factor X is initially synthesized in the liver. The two chains are formed from a single-chain precursor by the excision of two Arg residues and are held together by 1 or more disulfide bonds. Forms a heterodimer with SERPINA5. F10 is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
Protein Families	Druggable Genome, Protease, Transmembrane
Protein Pathways	Complement and coagulation cascades

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