Tnfrsf10b Mouse Recombinant Protein

CAT#: TP727572

Recombinant Mouse TRAIL R2/TNFRSF10B/DR5/CD262 (C-Avi-6His)



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CNY 3,140.00


货期*
2周

规格
    • 10 ug

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Specifications

Product Data
Species Mouse
Protein Source Human
Expression cDNA Clone or AA Sequence
Tag C-AVI&His
Buffer Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
Note Recombinant Mouse TNF-Related Apoptosis-Inducing Ligand Receptor 2 is produced by our Mammalian expression system and the target gene encoding Asn53-Ser177 is expressed with a Avi-6His tag at the C-terminus.
Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability 12 months from date of despatch
Reference Data
Locus ID 21933
UniProt ID Q9QZM4
Synonyms Tumor necrosis factor receptor superfamily member 10B/Death receptor 5/MK/CD262/Tnfrsf10b/Dr5/Killer
Summary Mouse tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is a member of the TNFR family which contains 1 death domain and 3 TNFR-Cys repeats. TNFRSF10B exhibits high structural and functional homology to TRAIL-R1 (DR-4). TNFRSF10B is highly expressed in heart, lung, lymphocytes, spleen and kidney. In addition, it is regulated by the tumor suppressor p53. TNFRSF10B is the receptor for the cytotoxic ligand TNFSF10/TRAIL. It promotes the activation of NF-kappa-B and is essential for ER stress-induced apoptosis. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis.
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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