Cynomolgus Recombinant Protein

CAT#: TP727545

Recombinant Cynomolgus CD80/B7-1 (C-Fc)



Need it in bulk or customized?
Get a free quote

CNY 3,140.00


货期*
2周

规格
    • 10 ug

Product images

Specifications

Product Data
Species Cynomolgus
Protein Source Human
Expression cDNA Clone or AA Sequence
Tag C-Fc
Buffer Lyophilized from a 0.2 um filtered solution of 50 mM Tris-HCl, 100 mM Glycine, pH 7.5.
Note Recombinant Cynomolgus T-lymphocyte Activation Antigen CD80 is produced by our Mammalian expression system and the target gene encoding Val35-Asn242 is expressed with a Fc tag at the C-terminus.
Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability 12 months from date of despatch
Reference Data
Synonyms T-lymphocyte activation antigen CD80; Activation B7-1 antigen; B7; CD80
Summary Cynomologous Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily.It is expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells.CD80 plays key, yet distinct roles in the activation of T cells. B7-1/CD80 and B7-2/CD86, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T- and B- cell responses. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Documents

Customer Reviews 
Loading...