Prostate Specific Antigen (KLK3) Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	Human
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Ile25-Pro261
Tag	C-His
Buffer	Supplied as a 0.2 um filtered solution of 20mM Tris-Hcl, 150mM NaCl, 1mM CaCl2, pH 7.5.
Note	Recombinant Human Kallikrein-3/Prostate-specific antigen is produced by our Mammalian expression system and the target gene encoding Ile25-Pro261 is expressed with a 6His tag at the C-terminus.
Storage	Store at < -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
Stability	12 months from date of despatch
Reference Data
Locus ID	354
UniProt ID	P07288
Synonyms	Prostate-specific antigen;PSA;Gamma-seminoprotein;Kallikrein-3;P-30 antigen;Semenogelase;KLK3;APS
Summary	KLK3, also known as APS, is short for Prostate-specific antigen. It is a 261 aa. protein which belongs to the peptidase S1 family and Kallikrein subfamily. This protein has 5 isforms produced by alternative splicing. It is a secreted protein and can forms a heterodimer with SERPINA5 which can inhibit its activity. KLK3 is also strongly inhibited by Zn2+, 100 times more abundant in semen than in serum. This inhibition is relieved by exposure to semenogelins, which are avid zinc binders. KLK3 can hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.
Protein Families	Druggable Genome, Protease, Secreted Protein
Protein Pathways	Pathways in cancer, Prostate cancer

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