IL18 Human Recombinant Protein
CNY 3,140.00
货期*
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规格
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Specifications
Product Data | |
Species | Human |
Protein Source | E. coli |
Expression cDNA Clone or AA Sequence |
M1-D193
|
Tag | N-His |
Buffer | Supplied as a 0.2 μm filtered solution of PBS, pH7.4. |
Note | Recombinant Human IL-18 is produced by our E. coli expression system and the target gene encoding M1-D193 is expressed with a His tag at the N-terminus. |
Storage | Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening.Please minimize freeze-thaw cycles. |
Stability | 12 months from date of despatch |
Reference Data | |
Locus ID | 3606 |
UniProt ID | Q14116 |
Synonyms | Interleukin-18; Iboctadekin; Interferon gamma-inducing factor; IFN-gamma-inducing factor;Interleukin-1 gamma; IL-1 gamma;GIF; IL-18; IL-1g; IL1F4; MGC12320 |
Summary | Interleukin-18 (IL-18) is a secreted protein that belongs to the IL-1family. IL-18 is a proinflammatory cytokine and can be expressed by multiple types of cells, including endothelial and epithelial cells, keratinocytes, gamma delta T cells, and phagocytes. This cytokine can modulate both innate and adaptive. Once binding to IL18R1 and IL18RAP, it can form a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. The combination of IL-18 and IL-12 can induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. |
Protein Families | Druggable Genome, Secreted Protein |
Protein Pathways | Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, NOD-like receptor signaling pathway |
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