Cynomolgus Recombinant Protein
CAT#: TP725538
Recombinant Cynomolgus GUCY2C (C-hFc)
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CNY 3,140.00
货期*
2周
规格
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Specifications
Product Data | |
Species | Cynomolgus |
Protein Source | Human 293 |
Expression cDNA Clone or AA Sequence |
Ser24-Gln430
|
Tag | C-hFc |
Buffer | Lyophilized from a 0.2 um filtered solution of PBS,pH7.4 |
Note | Recombinant Cynomolgus GUCY2C (C-hFc) is produced by Human Cells. The target gene encoding Ser24-Gln430 is expressed with a C-hFc tag. |
Storage | Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
Stability | 12 months from date of despatch |
Reference Data | |
Synonyms | GUCY2C,GUC2C,STAR,STA receptor,hSTAR,GC-C |
Summary | GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer. |
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