IL23 (IL23A) Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	Human 293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Arg20-Pro189 & Ile23-Ser328
Tag	C-6His
Buffer	Lyophilized from a 0.2 um filtered solution of PBS, 0.01%Tween 80, pH7.4
Note	Recombinant Human Interleukin-23 is produced by our Mammalian expression system and the target gene encoding Arg20-Pro189&Ile23-Ser328 is expressed with a 6His tag at the C-terminus.
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability	12 months from date of despatch
Reference Data
Locus ID	51561
UniProt ID	Q9NPF7
Synonyms	Interleukin-23; IL-23; SGRF; IL-23p19; CLMF p40; IL-12 subunit p40; NKSF2
Summary	Interleukin 23 (IL-23) is a member of the IL-12 family of cytokines. IL-23 is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The p19 subunit has homology to the p35 subunit of IL-12, as well as to other single-chain cytokines such as IL-6 and IL-11. The p40 subunit is homologous to the extracellular domains of the hematopoietic cytokine receptors. While p19 is expressed by activated macrophages, dendritic cells, T cells, and endothelial cells, p40 is only expressed by activated macrophages and dendritic cells. Both IL-12 and IL-23 induce proliferation and IFN-gamma production by human T cells. While IL-12 acts on both naive and memory human T cells, the effects of IL-23 is restricted to memory T cells.
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

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