Cynomolgus Recombinant Protein

Specifications

Product Data
Species	Cynomolgus
Protein Source	Human 293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Tyr25-His239
Tag	C-6His
Buffer	Lyophilized from a 0.2 um filtered solution of PBS,5% Trehalose, pH7.4.
Note	Recombinant Cynomolgus CD86 is produced by our Mammalian expression system and the target gene encoding Tyr25-His239 is expressed with a 6His tag at the C-terminus.
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability	12 months from date of despatch
Reference Data
Synonyms	T-lymphocyte activation antigen CD86 isoform 1; Activation B7-2 antigen; CD86
Summary	T-lymphocyte activation antigen CD86 (B7-2) is a type I membrane protein that belongs to the B7 family. CD86 is highly expressed on activated antigen presenting cells. CD86 plays an essential role for T-lymphocyte proliferation and interleukin-2 production through binding CD28 or CTLA-4. It is also involved in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Additionally, the CD86 participates innate immune responses by activating NF-κB-signaling pathway in macrophages. CD86 thus is predicted to be a promising candidate for immune therapy.

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