Haptoglobin (HP) Human Recombinant Protein
CAT#: TP724805
Recombinant Human Haptoglobin/Zonulin (C-His)
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CNY 3,140.00
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经常一起买 (1)
Anti-HP mouse monoclonal antibody, clone OTI4H5 (formerly 4H5)
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Specifications
Product Data | |
Species | Human |
Protein Source | Insect |
Expression cDNA Clone or AA Sequence |
V19-N406
|
Tag | C-8His |
Buffer | Supplied as a 0.2 um filtered solution of PBS, pH7.4 |
Note | Recombinant Human Haptoglobin is produced by Insect Cells and the target gene encoding V19-N406 is expressed with a 8His tag at the Câ€terminus. |
Storage | Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
Stability | 12 months from date of despatch |
Reference Data | |
Locus ID | 3240 |
UniProt ID | P00738 |
Synonyms | Haptoglobin; Zonulin; HP |
Summary | Haptoglobin(HP) is a secreted protein that belongs to the peptidase S1 family of serine proteases. It is expressed by the liver and secreted in plasma. Haptoglobin captures the free plasma hemoglobin to facilitate hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also has antibacterial activity and plays a role in regulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. Uncleaved haptoglobin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to foreign antigens. |
Protein Families | Druggable Genome, Protease, Secreted Protein, Transmembrane |
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