IL22 Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	Human 293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) A34-I179
Tag	C-6His
Buffer	Lyophilized from a 0.2 um filtered solution of PBS, pH7.2
Note	Biotinylated Recombinant Human Interleukin-22 is produced by Human 293 Cells. The target gene encoding A34-I179 is expressed with a 6His tag at the C terminus.
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability	12 months from date of despatch
Reference Data
Locus ID	50616
UniProt ID	Q9GZX6
Synonyms	Cytokine Zcyto18; IL-10-related T-cell-derived inducible factor; IL22; IL-22; IL-D110; IL-TIF; ILTIFIL-10-related T-cell-derived-inducible factor; IL-TIFMGC79382; interleukin 22; interleukin-22; MGC79384; TIFa; TIFIL-23; zcyto18
Summary	Interleukin-22 (IL22) is a cytokine that belongs to the IL-10 family or IL-10 superfamily, a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 initiated its biological activity by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein IL-22BP. IL-22 can contribute to immune disease through the stimulation of inflammatory responses, S1s and defensins. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut.
Protein Families	Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

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