Oncostatin M (OSM) Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	E. coli
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) A26-R221
Buffer	Lyophilized from a 0.2 um filtered solution of PBS, pH7.4
Note	Recombinant Human Oncostatin-M is produced by E.coli. The target gene encoding A26-R221 is expressed.
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability	12 months from date of despatch
Reference Data
Locus ID	5008
UniProt ID	P13725
Synonyms	MGC20461; oncostatin M; oncostatin-M; OSM
Summary	Oncostatin-M (OSM) is a glycoprotein that belongs to the interleukin-6 family of cytokines. OSM closely resembles leukemia inhibitory factor (LIF) in both structure and function. However, it is as yet poorly defined and is proving important in liver development, hematopoiesis, inflammation and possibly CNS development. OSM also plays a role in bone formation and destruction. OSM initiates its biological activities by binding to cell surface receptors that contain the protein gp130. OSM was previously identified by its ability to inhibit the growth of cells from melanoma and other solid tumors. Studies also showed that OSM, like LIF, IL-6 and G-CSF, can inhibit the proliferation of murine M1 myeloid leukemic cells and can induce their differentiation into macrophage-like cells.
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Stem cell relevant signaling - DSL/Notch pathway, Stem cell relevant signaling - JAK/STAT signaling pathway
Protein Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

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