LOXL2 Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	Human 293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Q26-Q774
Tag	N-8His
Buffer	Lyophilized from a 0.2 um filtered solution of PBS, pH 7.2
Note	Biotinylated Recombinant Human Lysyl Oxidase Homolog 2 is produced by Human 293 Cells. The target gene encoding Q26-Q774 is expressed with a 8His tag at the N terminus.
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability	12 months from date of despatch
Reference Data
Locus ID	4017
UniProt ID	Q9Y4K0
Synonyms	LOL2; LOR2; LOXL2; Lysyl Oxidase Homolog 2; lysyl oxidase related 2; lysyl oxidase-like 2; Lysyl oxidase-like protein 2; Lysyl oxidase-related protein 2; Lysyl oxidase-related protein WS9-14
Summary	Lysyl oxidase homolog 2 (LOXL2) is a secreted protein that belongs to the lysyl oxidase family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyzes the first step in the formation of crosslinks in collagens and elastin. LOXL2 is expressed in many tissues, with the highest expression in reproductive tissues, placenta, uterus and prostate, and is up-regulated in a number of cancers cells and tissues. LOXL2 changes the structure of histones and thus changes the shape of the cells, making it easier for the cancer cells to metastasize. LOXL2 expression could also be used as a molecular target in the prevention of breast cancer progression.
Protein Families	Druggable Genome, Secreted Protein

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