IL2 Receptor beta (IL2RB) Human Recombinant Protein
CAT#: TP724630
Recombinant Human Interleukin-2 Receptor Subunit Beta/IL2RB (N-Avi&His)
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CNY 3,140.00
货期*
5周
规格
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经常一起买 (1)
IL2RB mouse monoclonal antibody,clone OTI1D1
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Specifications
Product Data | |
Species | Human |
Protein Source | Human 293 |
Expression cDNA Clone or AA Sequence |
A27-T240
|
Tag | N-Avi&6His |
Buffer | Lyophilized from a 0.2 um filtered solution of PBS, pH7.4 |
Note | Recombinant human interleukin-2 receptor subunit beta is produced by Human 293 Cells. The target gene encoding A27-T240 is expressed with a Avi&;6His tag at the N terminus. |
Storage | Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
Stability | 12 months from date of despatch |
Reference Data | |
Locus ID | 3560 |
UniProt ID | P14784 |
Synonyms | Interleukin-2 receptor subunit beta;IL2RB;IL-2 receptor subunit beta;IL-2R subunit beta;High affinity IL-2 receptor subunit beta;CD122 |
Summary | Interleukin-2 receptor subunit beta (IL2RB) belongs to the type I cytokine receptor family and it is expressed in mononuclear cells. IL2RB contains a fibronectin type-III domain. IL2RB / CD122 is involved in T cell-mediated immune responses and is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. IL2RB is the receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. IL2RB might also be in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15. |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | Cytokine-cytokine receptor interaction, Endocytosis, Jak-STAT signaling pathway |
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