Complement C5 (C5) Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	E. coli
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) T678-R751
Buffer	Lyophilized from a 0.2 um filtered solution of 2umM Tris-HCl, 30umM NaCl. pH8.0
Note	Recombinant Human C5a is produced by E.coli. The target gene encoding T678-R751 is expressed.
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability	12 months from date of despatch
Reference Data
Locus ID	727
UniProt ID	P01031
Synonyms	Complement C5; C5a anaphylatoxin; C5a
Summary	Human Complement 5a (C5a) is a glycoprotein that belongs to a family of structurally and functionally related proteins known as anaphylatoxins. C5a is released from complement component C5, and act as a potent chemotactic factor for human peripheral blood neutrophils and monocytes. C5a is believed to play an important role in a number of inflammatory conditions. C5a can modulate the balance between activating versus inhibitory IgG Fc receptors on leukocytes, thereby enhancing autoimmune response. C5a also binds to a signaling G-protein coupled receptor (C5aR/CD88) and a non-signaling GPCR termed C5L2. Activation of Cd88 results in neutrophil chemotaxis and endothelial cell activation. It also triggers an oxidative burst in macrophages and neutrophils and induces the release of histamine in basophils and mast cells.
Protein Families	Druggable Genome
Protein Pathways	Complement and coagulation cascades, Prion diseases, Systemic lupus erythematosus

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