ALDH1A3 Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	E. coli
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Met1-Pro512
Tag	N-6His
Buffer	Lyophilized from a 0.2 um filtered solution of 20mM HEPES, 150mM KCl,1mM β-ME,0.5mM EDTA,pH7.5.
Note	Recombinant Human Aldehyde Dehydrogenase 1-A3 is produced by E.coli. The target gene encoding Met1-Pro512 is expressed with a 6His tag at the N terminus.
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability	12 months from date of despatch
Reference Data
Locus ID	220
UniProt ID	P47895
Synonyms	Aldehyde dehydrogenase family 1 member A3; ALDH1A3; Aldehyde dehydrogenase 6;Retinaldehyde dehydrogenase 3; RALDH-3; ALDH6
Summary	Aldehyde dehydrogenase 1 family member A3 (ALDH1A3), also known as retinaldehyde dehydrogenase 3 (RALDH3), is a member of the aldehyde dehydrogenase family known to metabolize a wide variety of aldehydes. ALDH1A3 specifically oxidizes retinal to retinoic acid (RA) and is differentially expressed in developing embryonic tissues and adult organs. It is required for the biosynthesis of normal levels of retinoic acid in the embryonic ocular and nasal regions The RA produced by ALDH1A3 in rodents contributes to the development of skin and hair follicles, brain, tooth buds, lungs, olfactory bulbs, kidneys, eyes, skeletal muscle and seminal vesicles. Recent studies showed ALDH1A3 could also be used as a marker of cancer stem cells to predict metastasis or clinical prognosis in many cancers.
Protein Families	Druggable Genome
Protein Pathways	Drug metabolism - cytochrome P450, Glycolysis / Gluconeogenesis, Histidine metabolism, Metabolic pathways, Metabolism of xenobiotics by cytochrome P450, Phenylalanine metabolism, Tyrosine metabolism

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