NKG2A (KLRC1) Human Recombinant Protein
CAT#: TP724608
Recombinant Human NKG2-A/NKG2-B Type II Integral Membrane Protein(N-His)
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CNY 3,140.00
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规格
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Specifications
Product Data | |
Species | Human |
Protein Source | Human |
Expression cDNA Clone or AA Sequence |
Arg100-Leu233
|
Tag | N-8His |
Buffer | Supplied as a 0.2 um filtered solution of PB, pH7.4 |
Note | Recombinant Human NKG2-A/NKG2-B Type II Integral Membrane Protein is produced by our Mammalian expression system and the target gene encoding Arg100-Leu233 is expressed with a 8His tag at the N-terminus. |
Storage | Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
Stability | 12 months from date of despatch |
Reference Data | |
Locus ID | 3821 |
UniProt ID | P26715 |
Synonyms | NKG2-A/NKG2-B type II integral membrane protein; CD159 antigen-like family member A; NK cell receptor A; NKG2-A/B-activating NK receptor; CD159a; KLRC1; NKG2A |
Summary | NKG2-A/NKG2-B is a type II integral membrane protein that contains one C-type lectin domain and belongs to the killer cell lectin-like receptor family. This family consists of transmembrane proteins expressed mainly in NK cells and characterized by type II membrane orientation and a C-type lectin domain. NKG2 is exclusively expressed in NK cells, not T or B cells. Studies have shown that NKG2 is a family of related cDNA clones, including NKG2A, NKG2B, NKG2C, and NKG2D, encoding type II integral membrane proteins with a C-type lectin domain at the extracellular C-terminus. NKG2 acts as a receptor for MHC class I HLA-E molecules, recognized by NK cells and some cytotoxic T cells. NKG2A and NKG2B are designated CD159a in the CD antigen nomenclature. Increased expression of NKG2A in tumor-infiltrating NK cells is emerging as a contributor to determining the poor prognosis of hepatocellular, lung, or other carcinomas and may be a predictive factor for tumor metastasis. |
Protein Families | Transmembrane |
Protein Pathways | Antigen processing and presentation, Graft-versus-host disease, Natural killer cell mediated cytotoxicity |
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