Timp1 (NM_011593) Mouse Recombinant Protein

Specifications

Product Data
Species	Mouse
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Mouse TIMP-1, the region of Cys27-Arg205, from gene Accession# NM_011593
Tag	C-His
Predicted MW	22 kDa
Concentration	lot specific
Purity	>90%, as determined by Coomassie stained SDS-PAGE.
Buffer	20 mM Tris, 150 mM NaCl, pH 8.0
Storage	Store at -80°C.
Stability	Unopened vial can be stored between 2°C and 8°C for up to 2 weeks, at -20°C for up to 6 months, or at -70°C or below until the expiration date. Aliquots can be stored between 2°C and 8°C for up to one week and stored at -20°C or colder for up to 3 months. Avoid repeated freeze/thaw cycles.
Bioactivity	Mouse TIMP-1 inhibits the activity of activated mouse MMP-9 (100 ng/mL). The IC50 = 90 ng/mL.
Endotoxin	Less than 1.0 EU per µg of protein as determine by the LAL method
Reference Data
RefSeq	NP_035723
Locus ID	21857
UniProt ID	P12032
Refseq Size	902
Cytogenetics	X 16.38 cM
Refseq ORF	615
Synonyms	Clgi; EPA; Timp; TIMP-1; TPA-S1
Summary	Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14 (By similarity). Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling.[UniProtKB/Swiss-Prot Function]

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