MCP2 (CCL8) (NM_005623) Human Recombinant Protein
CAT#: TP723788
Purified recombinant protein of Human chemokine (C-C motif) ligand 8 (CCL8 / MCP-2)
View other "MCP2" proteins (5)
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CNY 5,150.00
Cited in 1 publication. |
Product images
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Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
Human CCL8, the region of Gln24-Pro99, from gene Accession# NM_005623.2
|
Tag | Tag Free |
Predicted MW | 8.9 kDa |
Concentration | lot specific |
Purity | >98%, as determined by Coomassie stained SDS-PAGE. |
Buffer | 1 x PBS |
Storage | Store at -80°C. |
Stability | Unopened vial can be stored between 2°C and 8°C for up to 2 weeks, at -20°C for up to 6 months, or at -70°C or below until the expiration date. Aliquots can be stored between 2°C and 8°C for up to one week and stored at -20°C or colder for up to 3 months. Avoid repeated freeze/thaw cycles. |
Bioactivity | Bioactivity was measured by its property to chemoattract human THP-1 cells in a dose dependent manner. |
Endotoxin | Less than 0.01 ng per µg protein as determined by the LAL method |
Reference Data | |
RefSeq | NP_005614 |
Locus ID | 6355 |
UniProt ID | P80075 |
Refseq Size | 1351 |
Cytogenetics | 17q12 |
Refseq ORF | 297 |
Synonyms | HC14; MCP-2; MCP2; SCYA8; SCYA10 |
Summary | This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection. [provided by RefSeq, Sep 2014] |
Protein Families | Druggable Genome, Secreted Protein |
Protein Pathways | Chemokine signaling pathway, Cytokine-cytokine receptor interaction, NOD-like receptor signaling pathway |
Citations (1)
The use of this Proteins has been cited in the following citations: |
---|
Gene profile of fibroblasts identify relation of CCL8 with idiopathic pulmonary fibrosis
,null,
Respiratory Research
,PubMed ID 28057004
[CCL8]
|
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Other Versions
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LC417180 | CCL8 HEK293T cell transient overexpression lysate (as WB positive control) |
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TP720051 | Recombinant protein of human chemokine (C-C motif) ligand 8 (CCL8) |
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TP721120 | Purified recombinant protein of Human chemokine (C-C motif) ligand 8 (CCL8) |
CNY 3,140.00 |
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TP790101 | Purified recombinant protein of Human chemokine (C-C motif) ligand 8 (CCL8), esidues 24-99aa, with C-terminal DDK tag,expressed in human cells; |
CNY 6,650.00 |