RANTES (CCL5) (NM_002985) Human Recombinant Protein
CAT#: TP723778
Purified recombinant protein of Human chemokine (C-C motif) ligand 5 (CCL5 / RANTES)
View other "RANTES" proteins (5)
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CNY 4,090.00
CNY 1,999.00
CNY 2,700.00
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
Human RANTES, the region of Ser24-Ser91, from gene Accession# NM_002985
|
Tag | Tag Free |
Predicted MW | 7.9 kDa |
Concentration | lot specific |
Purity | >98%, as determined by Coomassie stained SDS-PAGE. |
Buffer | 0.22 µm filtered protein solution is in 30% Acetonitrile, 0.1% TFA (trifluoroacetic acid) |
Storage | Store at -80°C. |
Stability | Unopened vial can be stored between 2°C and 8°C for up to 2 weeks, at -20°C for up to 6 months, or at -70°C or below until the expiration date. Aliquots can be stored between 2°C and 8°C for up to one week and stored at -20°C or colder for up to 3 months. Avoid repeated freeze/thaw cycles. |
Bioactivity | The ED50 is 5-15 ng/ml, corresponding to a specific activity of 0.66-2.0 x 10^5 units/mg. |
Endotoxin | Less than 0.1 EU/µg (<0.01 ng/µg) protein as determined by the LAL method |
Reference Data | |
RefSeq | NP_002976 |
Locus ID | 6352 |
UniProt ID | P13501, D0EI67 |
Refseq Size | 1237 |
Cytogenetics | 17q12 |
Refseq ORF | 273 |
Synonyms | D17S136E; eoCP; RANTES; SCYA5; SIS-delta; SISd; TCP228 |
Summary | This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013] |
Protein Families | Druggable Genome, Secreted Protein, Transmembrane |
Protein Pathways | Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Epithelial cell signaling in Helicobacter pylori infection, NOD-like receptor signaling pathway, Prion diseases, Toll-like receptor signaling pathway |
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