CSNK1G2 (NM_001319) Human Recombinant Protein

CAT#: TP721005

Purified recombinant protein of Human casein kinase 1, gamma 2 (CSNK1G2)

Size: 10 ug 50 ug 500 ug 1 mg



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CNY 3,140.00


货期*
2周

规格
    • 10 ug

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经常一起买 (1)
CSNK1G2 mouse monoclonal antibody, clone OTI4H3 (formerly 4H3)
    • 100 ul

CNY 1,999.00
CNY 2,700.00

Specifications

Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Tag N-His
Predicted MW 47.6 kDa
Purity >95% as determined by SDS-PAGE and Coomassie blue staining
Buffer Supplied as a 0.2 um filtered solution of 20mM Tris-HCl, 500mM NaCl, 10% Glycerol, 1mM DTT, pH 8.0.
Storage Store at < -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
Stability Stable for at least 3 months from date of receipt under proper storage and handling conditions.
Endotoxin Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg)
Reference Data
RefSeq NP_001310
Locus ID 1455
UniProt ID P78368
Refseq Size 2921
Cytogenetics 19p13.3
Refseq ORF 1245
Synonyms CK1g2
Summary Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.[UniProtKB/Swiss-Prot Function]
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Hedgehog signaling pathway
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