Tissue Factor (F3) (NM_001993) Human Recombinant Protein
CAT#: TP720578
Recombinant protein of Homo sapien Tissue Factor/TF is produced by our mammalian expression system in human cells. The target protein is expressed with human TF fused with a polyhistidine tag at the C-terminus.
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CNY 3,140.00
Cited in 1 publication. |
Specifications
Product Data | |
Species | Human |
Expression Host | HEK293 |
Expression cDNA Clone or AA Sequence |
Gly34-Glu251
|
Tag | C-His |
Predicted MW | 27.0 kDa |
Concentration | lot specific |
Purity | >95% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | Lyophilized from a 0.2 um filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0. |
Storage | Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
Stability | Stable for at least 6 months from date of receipt under proper storage and handling conditions. |
Endotoxin | < 0.1 EU per µg protein as determined by LAL test |
Reference Data | |
RefSeq | NP_001984 |
Locus ID | 2152 |
UniProt ID | P13726 |
Cytogenetics | 1p21.3 |
Synonyms | CD142; TF; TFA |
Summary | This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces, for example, on monocytes. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. Platelets and monocytes have been shown to express this coagulation factor under procoagulatory and proinflammatory stimuli, and a major role in HIV-associated coagulopathy has been described. Platelet-dependent monocyte expression of coagulation factor III has been described to be associated with Coronavirus Disease 2019 (COVID-19) severity and mortality. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Aug 2020] |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | Complement and coagulation cascades |
Citations (1)
The use of this Proteins has been cited in the following citations: |
---|
Tumour imaging by the detection of fibrin clots in tumour stroma using an anti-fibrin Fab fragment
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Scientific Reports
,PubMed ID 27009516
[F3]
|
Documents
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Resources
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
PH303142 | F3 MS Standard C13 and N15-labeled recombinant protein (NP_001984) |
CNY 19,520.00 |
|
TP303142 | Recombinant protein of human coagulation factor III (thromboplastin, tissue factor) (F3), 20 µg |
CNY 2,900.00 |
|
TP504046 | Purified recombinant protein of Mouse coagulation factor III (F3), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug |
CNY 7,106.00 |
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