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LDL Receptor (LDLR) (NM_000527) Human Recombinant Protein
CAT＃: TP720505
Recombinant protein of human low density lipoprotein receptor (LDLR), Ala22 - Arg788
View other "LDL Receptor" proteins (8)
|
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CNY 3,140.00
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Species | Human |
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence |
Ala22-Arg788
|
| Tag | C-His |
| Predicted MW | 86 kDa |
| Concentration | lot specific |
| Purity | >95% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | Lyophilized from a 0.2 um filtered solution of 20mM HEPES,150mM Nacl,PH7.4. |
| Storage | Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
| Stability | Stable for at least 3 months from date of receipt under proper storage and handling conditions. |
| Endotoxin | < 0.1 EU per µg protein as determined by LAL test |
| Reference Data | |
| RefSeq | NP_000518 |
| Locus ID | 3949 |
| UniProt ID | P01130, A0A024R7D5 |
| Cytogenetics | 19p13.2 |
| Synonyms | FH; FHC; FHCL1; LDLCQ2 |
| Summary | The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010] |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transmembrane |
| Protein Pathways | Endocytosis |
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| LC400183 | LDLR HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC434371 | LDLR HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 1,470.00 |
|
| LC434377 | LDLR HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 1,470.00 |
|
| LY400183 | Transient overexpression lysate of low density lipoprotein receptor (LDLR) |
CNY 3,080.00 |
|
| LY434371 | Transient overexpression lysate of low density lipoprotein receptor (LDLR), transcript variant 6 |
CNY 4,840.00 |
|
| LY434377 | Transient overexpression lysate of low density lipoprotein receptor (LDLR), transcript variant 4 |
CNY 4,840.00 |
|
| PH300006 | LDLR MS Standard C13 and N15-labeled recombinant protein (NP_000518) |
CNY 19,520.00 |
|
| TP300006 | Recombinant protein of human low density lipoprotein receptor (LDLR), 20 µg |
CNY 2,900.00 |
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