Bmt2 (NM_175312) Mouse Recombinant Protein

Specifications

Product Data
Species	Mouse
Expression Host	HEK293T
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) >MR213217 protein sequence Red=Cloning site Green=Tags(s) MEPGPGGRGAARGQRPPNAAQPREQERKLEQEKLSGVVKSVHRRLRKKYREVGDFDKIWREHCEDAETLC EYAVAMKNLADNHWAKTCEGEGRIEWCCSVCREYFQNGGKRKALEKDEKRAVLATKTTPALNVHESSKLE GPLTNLSFTSPDFITELLQASGKIRLLDVGSCFNPFLKFEEFLTVGIDIVPAVESVYKCDFLNLQLQQPL QLAQDAIDAFLKQLRNPIDALPGELFHVVVFSLLLSYFPSPYQRWICCKKAHELLVLNGLLLIITPDSSH QNRHAMMMKSWKIAIESLGFKRFKYSKFSHMHLMAFRKTSLKTTSDLVSRNYPGMLYIPQDFNSVEEEEY SNTSCYVRSDLEDEQLAYGFTELPEAPYDSDSGESQASSIPFYELEDPILLLS TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-MYC/DDK
Predicted MW	46 kDa
Concentration	>0.05 µg/µL as determined by microplate BCA method
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Note	For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage	Store at -80°C after receiving vials.
Stability	Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq	NP_780521
Locus ID	101148
UniProt ID	Q8BXK4
Refseq Size	4147
Cytogenetics	6 A1
Refseq ORF	1212
Synonyms	AI666701; B630005N14Rik
Summary	S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.[UniProtKB/Swiss-Prot Function]

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