Lmtk3 (NM_001005511) Mouse Recombinant Protein

Specifications

Product Data
Species	Mouse
Expression Host	HEK293T
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) >MR211980 representing NM_001005511 Red=Cloning site Green=Tags(s) MPAPGALILLAAVSASGCLASPAHPDGFALSRAPLAPPYAVVLISCSGLLAFIFLLLTCLCCKRGDVRFK EFENPEGEDCSGEYTPPAEETSSSQSLPDVYILPLAEVSLPMPAPQPPHSDISTPLGLSRQHLSYLQEIG SGWFGKVILGEVFSDYSPAQVVVKELRASAGPLEQRKFISEAQPYRSLQHPNVLQCLGVCVETLPFLLIM EFCQLGDLKRYLRAQRPPEGMSPELPPRDLRTLQRMGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTV RIGDYGLAHSNYKEDYYLTPERLWVPLRWAAPELLGELHGSFVLVDQSRESNVWSLGVTLWELFEFGAQP YRHLSDEEVLAFVVRQQHVKLARPRLKLPYADYWYDILQSCWRPPAQRPSASDLQLQLTYLLSERPPRPP PPPPPPRDGPFPWPWPPSHSAPRPGTLSSQFPLLDGFPGADPDDVLTVTESSRGLNLECLWEKARRGAGR GGGAPPWQPASAPPAPHTNPSNPFYEALSTPSVLPVISARSPSVSSEYYIRLEEHGSPPEPLFPNDWDPL DPGVPGPQAPQTPSEVPQLVSETWASPLFPAPRPFPAQSSGSGGFLLSGWDPEGRGAGETLAGDPAEVLG EQGTAPWAEEEEEESSPGEDSSSLGGGPSRRGPLPCPLCSREGPCSCLPLERGDAVAGWGDHPALGCPHP PEDDSSLRAERGSLADLPLVPPTSAPLEFLDPLMGAAAPQYPGRGPPPAPPPPPPPPRASAEPAASPDPP SALASPGSGLSSPGPKPGDSGYETETPFSPEGAFPGGGAAEEEGVPRPRAPPEPPDPGAPRPPPDPGPLP LPGSQEKPTFVVQVSTEQLLMSLREDVTKNLLGDKGSTPGETGPRKAGRSPANREKGPGPNRDLTSLVSR KKVPSRSLPVNGVTVLENGKPGVPDMKEKVAENGLESPEKEERALVNGEPMSPEAGEKVLANGVLMSPKS EEKVAENGVLRLPRNTERPPEIGPRRVPGPWEKTPETGGLAPETLLDRAPAPCEAALPQNGLEMAPGQLG PAPKSGNPDPGTEWRVHESGGAPRAPGAGKLDLGSGGRALGGVGTAPAGGPASAVDAKAGWVDNSRPLPP PPQPLGAQQRRPEPVPLKARPEVAQEEEPGVPDNRLGGDMAPSVDEDPLKPERKGPEMPRLFLDLGPPQG NSEQIKAKLSRLSLALPPLTLTPFPGPGPRRPPWEGADAGAAGGEAGGAGAPGPAEEDGEDEDEDEEDEE AAGSRDPGRTREAPVPVVVSSADGDTVRPLRGLLKSPRAADEPEDSELERKRKMVSFHGDVTVYLFDQET PTNELSVQGTPEGDTEPSTPPAPPTPPHPTTPGDGFPNSDSGFGGSFEWAEDFPLLPPPGPPLCFSRFSV SPALETPGPPARAPDARPAGPVEN TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-MYC/DDK
Predicted MW	150.9 kDa
Concentration	>0.05 µg/µL as determined by microplate BCA method
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Note	For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage	Store at -80°C after receiving vials.
Stability	Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq	NP_001005511
Locus ID	381983
UniProt ID	Q5XJV6, A0A0R4J0W7
Refseq Size	4867
Cytogenetics	7 B3
Refseq ORF	4272
Synonyms	aatyk3; BC059845
Summary	Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (By similarity). Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (PubMed:24760852).[UniProtKB/Swiss-Prot Function]

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