Alpha-Synuclein / SNCA (1-140) Human Protein
CAT#: SA6001
Alpha-Synuclein / SNCA (1-140) human recombinant protein, 0.1 mg
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CNY 7,900.00
货期*
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规格
Cited in 2 publications. |
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
|
Concentration | lot specific |
Purity | >95% pure by SDS-PAGE. |
Buffer | Presentation State: Purified State: Liquid purified protein Buffer System: 20 mM Tris-HCl buffer (pH 7.5) containing 0.1 M NaCl, 1 mM MgCl2 |
Preparation | Liquid purified protein |
Protein Description | Purified human recombinant alpha-Synuclein (amino acids 1-140). |
Note | Real molecular weight on SDS-PAGE will be shift up (see picture below). |
Storage | Store at 2 - 8°C for up to two weeks or (in aliquots) at -20°C to -70°C. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Endotoxin | < 1.0 EU per 1 microgram of protein (determined by LAL method) |
Reference Data | |
RefSeq | NP_000336 |
Locus ID | 6622 |
UniProt ID | P37840 |
Cytogenetics | 4q22.1 |
Synonyms | NACP; PARK1; PARK4; PD1 |
Summary | Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016] |
Protein Families | Druggable Genome |
Protein Pathways | Alzheimer's disease, Parkinson's disease |
Citations (2)
The use of this Proteins has been cited in the following citations: |
---|
Disease Progression-Dependent Expression of CD200R1 and CX3CR1 in Mouse Models of Parkinson’s Disease
,null,
Aging and Disease
,PubMed ID 32257540
[SNCA]
|
A stress-enhanced model for discovery of disease-modifying gene: Ece1-suppresses the toxicity of α-synuclein A30P.
,null,
Neurobiology of disease
,PubMed ID 29524599
[SNCA]
|
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