Hepatocyte growth factor / HGF Human Protein

Specifications

Product Data
Species	Human
Expression Host	Insect
Predicted MW	78 kDa
Concentration	lot specific
Purity	>85% pure by SDS-PAGE and visualised by silver stain.
Buffer	Presentation State: Purified State: Lyophilized without preservatives. Buffer System: 50 mM Acetic Acid with BSA as stabilizer.
Preparation	Lyophilized without preservatives.
Protein Description	Recombinant human HGF is a 78.0 kDa protein.
Storage	The lyophilized protein is stable at -20°C for one year from despatch. Reconstituted human HGF is stable for three months when stored in working aliquots at -20°C. Avoid repeated freezing and thawing.
Bioactivity	Biological: Human HGF is fully biologically active when compared to standards. The activity was assayed for scattering activity in the MDCK cell assay. The ED50 was for this effect is typically at 0.5-1.0 ng/ml.
Endotoxin	< 0.1 ng per µg of HGF
Reference Data
RefSeq	NP_000592
Locus ID	3082
UniProt ID	P14210
Cytogenetics	7q21.11
Synonyms	Scatter factor, Hepatopoeitin-A, HPTA
Summary	This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015]
Protein Families	Adult stem cells, Druggable Genome, ES Cell Differentiation/IPS, Protease, Transmembrane
Protein Pathways	Cytokine-cytokine receptor interaction, Focal adhesion, Melanoma, Pathways in cancer, Renal cell carcinoma

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